In those with multilobular necrosis, 50% reduction in the death/transplantation rate was observed after steroid treatment ( P = .018). Fifteen (62.5%) patients receiving corticosteroids survived without transplantation compared with 9 (37.5%) that did not receive steroids ( P = .149). Liver biopsy was performed 2-days (median, IQR 1-3) after admission. Corticosteroids were initiated 2.7 ± 3.8 days after admission. Of the 48 cases, 24 received corticosteroids (initial dose of 45 ± 12 mg prednisolone). Resultsįorty-eight patients were included, 24 (50%) recovered and the other half underwent liver transplantation or died within 3-months. The clinical manifestation and histopathological features of steroid and non-steroid groups were compared and their relationship with corticosteroids response was evaluated. This study included consecutive patients with acute indeterminate hepatitis admitted to a single hospital and underwent a liver biopsy. The aims of this study were to analyse the clinical and pathological features of patients with IAH to define predictors of corticosteroid responsiveness. Corticosteroids are often used in the management of these patients but criteria for the selection of patients for this intervention are arbitrary. Treatment of patients with severe indeterminate hepatitis (IAH) is an unmet need.
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